v1
T1 + Ttot = ∅
v10
∅ = Tstar1 + Ttot
v11
∅ = Tstar1 + Ttot
v12
∅ = T2 + Ttot
v13
∅ = T2 + Ttot
v14
T2 + Ttot = ∅
v15
T2 = Tstar2
v16
Tstar2 = T2
v17
T2 + Ttot = ∅
v18
T2 + Ttot = ∅
v19
Tstar2 + Ttot = ∅
v2
T1 = Tstar1
v20
Tstar2 + Ttot = ∅
v21
Tstar2 + Ttot = ∅
v22
∅ = VI
v23
VI = VNI
v24
VI = ∅
v25
VI = ∅
v26
∅ = VI
v27
VI = ∅
v28
∅ = VI
v29
VNI = ∅
v3
Tstar1 = T1
v30
∅ = E1
v31
∅ = E1
v32
E1 = ∅
v33
E1 = ∅
v34
E1 = E2
v35
∅ = E1
v36
∅ = E2
v37
E2 = ∅
v38
E2 = ∅
v4
T1 + Ttot = ∅
v5
∅ = T1 + Ttot
v6
∅ = T1 + Ttot
v7
Tstar1 + Ttot = ∅
v8
Tstar1 + Ttot = ∅
v9
Tstar1 = Tstar2
Assignment rules
viruscopiesperml = VNI + VI
Function definitions
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
Immuno-modulatory strategies for reduction of HIV reservoir cells.
J. Theor. Biol. 2015;
372
:
146-158
- PubMed: 25701451
- PubMed Central: PMC4390551
- DOI: 10.1016/j.jtbi.2015.02.006
- ISSN: 1095-8541
- URL: http://ncbi.nlm.nih.gov/pubmed/25701451
Abstract
Antiretroviral therapy is able to suppress the viral load to below the detection limit, but it is not able to eradicate HIV reservoirs. Thus, there is a critical need for a novel treatment to eradicate (or reduce) the reservoir in order to eliminate the need for a lifelong adherence to antiretroviral therapy, which is expensive and potentially toxic. In this paper, we investigate the possible pharmacological strategies or combinations of strategies that may be beneficial to reduce or possibly eradicate the latent reservoir. We do this via studies with a validated mathematical model, where the parameter values are obtained with newly acquired clinical data for HIV patients. Our findings indicate that the strategy of reactivating the reservoir combined with enhancement of the killing rate of HIV-specific CD8+ T cells is able to eradicate the reservoir. In addition, our analysis shows that a targeted suppression of the immune system is also a possible strategy to eradicate the reservoir.
No additional notes are available for this model.